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Keywords: elderly, hypertension, HYVET, older adults, treatment In the pilot study, subjects aged over 80 years, with a sustained blood. Kardiol Pol. Jul;66(7); discussion [HYVET study – treatment for hypertension]. [Article in Polish]. Zalewska J(1). Author information. “In the main HYVET study, we aimed to resolve persistent areas of clinical uncertainty about the relative benefits and risks of antihypertensive.

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The role of blood pressure control in preventing complications of hypertension.

Whilst each additional GDS point at baseline also increased these risks, the study was not huvet to evaluate this association. Subjects were then randomized to one of sudy treatment arms, the thiazide like diuretic, indapamide sustained release, 1. In that vein, some have expressed significant concerns with over-treatment of hypertension in the elderly, citing the risks of polypharmacy and stduy fact that elderly patients are prone to ztudy and orthostatic syncope, etc.

It is possible that the difference in stroke rates would have reached statistical significance had the trial not been stopped early. Initially blood pressures were recorded with either a mercury sphygmomanometer or a validated automated device, but at the end of the trial a validated automated device was used in the majority of centres [ 13 ].

Having recruited large numbers of patients from Eastern Europe and China, the authors were criticized for not appreciating the increased prevalence of cerebrovascular events in these populations, when compared with adults from Western Europe — a factor which may exaggerate the potential benefit arising from active therapy [ 14 ].

In common with many other clinical trials in older people, the inclusion criteria also required that subjects be in relatively good physical and mental health individuals with dementia and those resident in nursing homes were excludedquestioning the applicability of the trial outcomes to the real life setting [ 1316 ]. Once again, the relative well being of the trial participants limits the potential applicability of these data to the general population.


More recently, additional data from this cohort has been published suggesting that appropriate anti-hypertensive therapy may lead to a reduction in incident cognitive impairment and fractures, whilst a 1 year open label extension of the main study confirmed many of the original trial findings.

HYVET – Wiki Journal Club

Hypertension — treated and untreated. At 2 tsudy there were no significant changes in serum potassium, uric acid, glucose and creatinine between the trial arms [ 13 ]. Influence of antihypertensive drug treatment on morbidity and mortality in patients over the age of 60 years. This article has been cited by other articles in PMC.

[HYVET study – treatment for hypertension].

Beckett NS, et al. Medical Research Council trial of treatment of hypertension in older adults: Although the model requires further validation, it suggests that cognitive change in those aged over 80 years is small, depends on baseline cognitive shudy and the relative efficacy of anti-hypertensive treatment [ 25 ].

The s saw publication of landmark data demonstrating the benefits of anti-hypertensive therapy [ 1 — 3 ]. Antihypertensive drugs in very old people: Those on antihypertensives at baseline had their medications stopped prior to placebo run-in. Support Center Support Center.

Trial participants receiving double-blind treatment at their final visit within the main study were deemed eligible for inclusion. Secondary outcomes included rates of fatal stroke, all-cause mortality, and CV events. Please review our privacy policy. Early trials in the field of hypertension focused on adults in their fifties and sixties.


Some have interpreted HYVET as a negative study, since the P value for the primary outcome of stroke did not reach statistical uyvet. This may reflect the relative physical well being of the ztudy population [ 24 ]. This page was last modified on 11 Januaryat Br J Clin Pharmacol. Mancia G, Grassi G.

This appeared to detect small differences between the two trial arms, in favour of treatment. Furthermore, a failure to routinely identify vertebral fractures and difficulties in data collection may be sources of error.

The Hypertension in the Very Elderly Trial – latest data

Given this uncertainty, the Hypertension in the Very Elderly Trial HYVET was commissioned with an open label pilot undertaken to determine trial feasibility [ 1112 ]. However, at the time of the final intention-to-treat hyver in Octoberthis significant reduction in the primary outcome measure failed to show statistical significance — the reasons for which have never been elaborated. Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension.

After a 2-month placebo run-in phase, 3, patients were randomized to active treatment or placebo with stratification according to age and sex. Mortality by race-sex and age.