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Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

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Due to its perforahs, EPS often remains unrecognized, but the diagnosis should always be taken into account in children, in whom annular lesions on the face and neck can be visualized.

The patient had been treated with oral cephalexin for 2 weeks and topical erythromycin solution for several weeks, without improvement. In addition to a marked increase in the amount and thickness of papillary dermal elastic serpiginnosa, a chronic inflammatory infiltrate containing lymphocytes, macrophages, or multinucleated giant cells may be present in the dermis at the sites of perforation.

Oxford Ellastosis Press; Sign in to access your subscriptions Sign in to your personal account. J Am Acad Dermatol. Find articles by Soo-Chan Kim. Also, patients perrorans with penicillamine are prone to develop EPS. Oxford Textbook of Medicine. Tazarotene is the first receptor-selective topical retinoid approved for the treatment of plaque psoriasis. Patient 2 then discontinued tazarotene therapy, and her disease flared. Imiquimod therapy for elastosis perforans serpiginosa.

Lippincott Williams and Wilkins; D-penicillamine-induced elastosis perforans serpiginosa in a child with juvenile rheumatoid arthritis. Penicillamine-induced elastosis of the mucosal lip.


Biopsy specimen demonstrating transepidermal elimination of altered elastic fibers. To our knowledge, this is the first report of EPS being successfully treated with tazarotene. Many of the elastic fibers appeared clumped and thickened.

Verhoeff-van Gieson staining showed dense clumps of altered elastic fibers in the papillary dermis. However, others, like Saxena did not show a positive response to numerous sessions using these lasers, and in turn, CO 2 laser caused scarring [ 16 ].

The result is a papular eruption that is usually arranged serpiginously, annularly, or arcuately. D-penicillamine, elastosis perforans serpiginosa, lumpy-bumpy elastic fibers. EPS most commonly appears during early adulthood years but may been seen in early elasotsis or late in life.

Purchase access Subscribe now. Acquired serpiginoas of elastic tissue: The differential diagnosis should also include granuloma annulare, dermatophyte infections, sarcoidosis, skin calcinosis and porokeratosis of Mibelli [ 1 ]. Saxena M, Tope WD.

Elastosis perforans serpiginosa: a review of the literature and our own experience

Indian Dermatol Online J. Imiquimod therapy for elastosis perforans serpiginosa. Patient 1 has tried to taper her usage of tazarotene but notices flares on discontinuation. Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.

Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson’s disease with penicillamine. Characteristic for EPS skin lesions within face A and left upper extremity B, C — papular keratotic lesions fuced together in serpiginous arrangement.

Cutaneous lupus erythematosus chronic: YAG, and dye lasers.

Numerous treatment modalities have been described, including dry ice 8cellophane tape stripping 813electrodessication and curettage 14cryotherapy 13 – 15intralesional and topical corticosteroid therapy 1516topical calcipotriol 14topical tretinoin 141517oral isotretinoin 1415topical tazarotene 15topical imiquimod 18topical glycolic or salicylic acid therapy 1417narrow band ultraviolet B radiation 14pulsed dye laser, Er: A list of possible co-morbidities of EPS is shown in Table 1 [ 3 — 6 ].


You can help Wikipedia by expanding it. Though numerous treatment modalities have been described in the literature, most are not very effective. Copyright American Medical Association. The dermatological examination revealed some reduced psoriatic plaques on the skin of the elbows and scalp.

Brown, MD ; Jeffrey P. How to cite this article: Tazarotene is an effective therapy for elastosis perforans serpiginosa. Find articles by Si-Hyung Lee.

Elastosis Perforans Serpiginosa

The data from the five Korean patients with EPS further support these findings: This page was last edited on 2 Mayat Received Jan 15; Accepted Feb Elastosis perforans serpiginosa is considered as mild dermatosis, which is not accompanied by involvement of other organs [ 2 ]. Treatment with topical tretinoin including topical 0. The last subtype, idiopathic one, may be associated with genetic basis of the autosomal dominant type of inheritance.

A year-old man presented to Gangnam Severance Hospital with a 2-year history of skin eruptions on his neck, which were refractory to topical antifungal or steroid treatment. YAG laser 16and carbon dioxide laser therapy 15 ,