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Adenomatoid odontogenic tumor (AOT), a benign (hamartomatous) lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor (AOT) is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. To acquire additional. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. It appears mostly in young patients and females, the maxillary.

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This research aimed to study and discuss the subject by the immunohistochemical detection of cytokeratins, laminin, collagen IV, PCNA and p53 in 8 tumor samples and 8 dental follicle samples containing reduced enamel epithelium.

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CK14 was detected in the cords of cubic and peripheral polyhedrical cells, as well as in the fusiform and stellated cells adjacent to the solid areas of the tumor. There are flakes of radio-opaque areas inside the lesion.

We would also emphasize that the AOT could remain intraosseous or peripheral in the jaw bones, depending on the spatial position of the tumor and associated tooth. Larger lesions cause a painless expansion of the bone [ 38 ].

The maxillary arch is the predominant site of occurrence, being almost twice as frequent as that of the mandible, and the anterior part of the jaw is more frequently involved than the posterior part.

There is no doubt about the AOT origin from the odontogenic epithelium; however the cell directly involved in the pathogenesis is still under discussion. Adenomatoid odntogenic tumor associated with dentigerous cyst in posterior maxilla: Not rarely did these structures present a thin layer of the eosinophilic material in its internal surface.


How to cite this URL: Correlation of MRI with histopathological findings. Int J Oral Health Sci ;4: AOT usually occurs within the tooth bearing areas of jaws and often found in association with impacted teeth.

The intraoral periapical radiograph is the best radiograph to show radiopacities in AOT as discrete foci having a flocculent pattern within radiolucency even with minimal calcified deposits.

The adenomatoid odontogenic tumor AOT is a clinically benign lesion. To receive news and publication updates for Case Reports in Dentistry, enter your email address in the box below.

Case Reports in Dentistry

Microscopically, the tumor is composed of spindle-shaped epithelial cells that form sheets, strands, or whorled masses of cells in a scant fibrous stroma. Laminin was clearly expressed in the zone of the basal membrane, both of the epithelium and of the blood vessels, a pattern that was followed by collagen IV; however, with weaker adenomatoi, not rarely absent next to the epithelium.

The large adenomatoid structures, resulting from the circular tridimensional, “tubular” configuration of the columnar cells and cylindrical superficial cells of the REE due to its hamartomatous growth, would be formed in recent tumors, right from adenomaoid onset. It is known that at the end of amelogenesis, post-secretory ameloblasts synthesize a material similar to the basal lamina, which adheres to the newly formed enamel.

August 26, Modification: A new odontogenic entity? Excised lesion Click here to view. In stafne reported first series of AOT under the title epithelial tumors associated with developments cyst of maxilla. Delayed eruption of a permanent tooth or a regional swelling of the jaws may be the first symptom. In this case, AOT was associated with the lateral maxillary incisor.


Stern, Oral and Maxillofacial Pathology: Two incubations 5 min. It labelled, from weakly to strongly, most of the cells in the solid areas, adenomatoid structures, cords of cubic and polyhedrical cells, and was practically absent or weak in the fusiform cells and in the stellated addnomatoid interspersed in the solid areas Figure 2.

Immunohistochemical demonstration of an enamel sheath protein, sheatlin, in odontogenic tumors.

Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry

Females are more commonly affected than males with a ratio of 2: Adenomatoid odontogenic tumor with features of calcifying epithelial odontogenic tumor. Post operative intraoral view Click here to view. In one of the tumors, occasional cell foci with a squamous appearance were observed.

Immunohistochemical detection and distribution of enamelysin MMP in human odontogenic tumors. Adenoid ameloblastoma with dentinoid: In this paper, a case of AOT in the anterior maxillary region associated with a permanent lateral incisor will be reported. The buccal cortex was expanded, and the surface of the swelling was smooth with a normal color of overlying mucosa.